Although the pathogenesis of osteoarthritis is still unclear, the development and progression of this disease is always accompanied by changes in expression pattern of a large set of genes [10, 11], such as lncRNAs Several differentially expressed lncRNAs, such as lncRNA lncRNA HOTAIR and lncRNA UFC1 have been proved to be essential players in osteoarthritis [12, 13]. The gene discussed is HOTAIR; the disease is osteoarthritis.