ACHE and Alzheimer disease: At baseline, the mean age of participants was 72 years (range 55 to 86), 55% were women, 52% were classified as AD of moderate severity based on MMSE score of ≤ 20 (48% had dementia of mild severity based on MMSE score of ≥ 21), and 89% were taking an acetylcholinesterase inhibitor and/or memantine.