The most widely used tumour models to study specific antitumor T cell responses are syngeneic tumours expressing a specific ovoalbumin (OVA)-derived antigenic peptide presented by H-2 Kb in combination with adoptive transfer of CD8+ T cells from OT-I mice expressing a transgenic TCR that specifically recognises the combination of OVA peptide and H-2 Kb [41]. The gene discussed is CD8A; the disease is neoplasm.