Further, Wan et al. [41] reported that, YB-1 +/− animals displayed markedly reduced tubular injury, immune cell infiltration and renal fibrosis following ureteral obstruction, and, the therapeutic forced nuclear compartmentalization of phosphorylated YB-1 by the small molecule HSc025 attenuated fibrosis. The gene discussed is YBX1; the disease is renal fibrosis.