As loss of PP2A in podocyte leads to proteinuria and glomerulopathy, to gain further insight into its molecular mechanisms, primary podocyte from the Pod-PP2A-KO mice and the control were cultured, employing label-free nano-LC − MS/MS technology on a Q-exactive followed by SIEVE processing, then, the one of the most interesting protein is Y-box binding protein-1 (YB-1). Here, PTPA is linked to lipoprotein glomerulopathy.