There are 36 subpathways (including the same subpathway at different molecular features) with a hazard ratio (HR) > 1 and 102 with a HR < 1, 19 significantly associated with survival outcome (P < 0.05) (Fig. 6a and Additional file 5: Figure S3), such as subpathways involved in Wnt signaling pathway on expression level, Ras signaling pathway on methylation level, ErbB signaling pathway on copy number variation level from BLCA-cisplatin. Here, EGFR is linked to bladder transitional cell carcinoma.