In this study, data from 89 patients with lung adenocarcinoma (LUAD) aged 35 years or younger were used to determine the mutation status of 59 cancer-related genes by next-generation sequencing (NGS) technology, and fusions of ALK and c-ros oncogene 1 (ROS1) were identified, which provides further insight into the molecular features of young patients with LUAD. Here, ROS1 is linked to cancer.