In nephrotic-range disease, we hypothesized that the causes why spot urine PCR was not associated with 24HP were as follows: In nephrotic syndrome, kidney function may decrease because of causes such as dehydration, and increase of sodium reabsorption [14]; as a result, megalin function declines, affecting its role in the reabsorption of proteins in urine (2). The gene discussed is LRP2; the disease is nephrotic syndrome.