Additionally, the IL-38/IL-36R axis has been reported to have a vital role in the pathogenic mechanism of many diseases, including inflammatory autoimmune diseases such as SLE [54], RA [29], AS [55], IBD [29], psoriasis [56], pSS [57], asthma [58], retinopathy [59], hepatitis [60], coronary artery diseases and cancer [61], and myocardial infarction [62]. This evidence concerns the gene IL1F10 and peeling skin syndrome.