Furthermore, IL-36 procytokines and IL-36Ra levels are further increased at the peak of psoriasis in a mouse model induced by IMQ, a TLR7 agonist that activates the innate immune response and induces skin inflammation, although IL-38 expression is reduced dramatically at the same time, these findings are in accordance with those observed in psoriasis patients [29]. This evidence concerns the gene TLR7 and psoriasis.