To examine if there is a relationship between the replication levels of a Flaviviridae virus and the expression of DDC in vivo, we quantified by RT-qPCR the DDC mRNA levels in 12 liver fine-needle biopsy specimens from patients with liver fibrosis due to chronic HCV infection, that have been previously characterized for their HCV RNA quantity, as well as the expression profile of PI3K/AKT target genes [68]. This evidence concerns the gene AKT1 and Hepatic fibrosis.