Treatments for endometriosis that aim to alter E2 and P4 signaling are currently in use, such as combined oral contraceptives (COCs), progestins, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors, and others are still under development, such as GnRH antagonists, selective estrogen receptor modulators (SERMs), and selective progesterone receptor modulators (SPRMs) [211,212,213] (Table 2). Here, PGR is linked to endometriosis.