Further confirming the comprehensive disruption of P4 signaling in endometriosis, HOXA10 [156], IGFBP1 [134], PLZF [144], MIG-6 [144], and CRISPLD2 [51], all PGR targets implicated in endometrial function based on mouse studies, have been shown to be dysregulated in endometriosis patients. The gene discussed is ZBTB16; the disease is endometriosis.