NOTCH1 and other Notch signaling molecules have been found decreased in endometrium from women and baboons with endometriosis, and silencing of NOTCH1 impaired decidualization in isolated human endometrial stromal cells potentially by downregulation of FOXO1 [157], reminiscent of P4 resistance in endometriosis. This evidence concerns the gene NOTCH1 and endometriosis.