Another study demonstrated that forced overexpression of YAP promotes resistance to EGFR-TKI erlotinib in EGFR mutant NSCLC cells, and that knock down of YAP increases the cytotoxicity of erlotinib to NSCLC cell line H1975 (L858R + T790M mutations) [86]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.