Two recent studies that investigated the role of EGFR in regulating PD-L1 expression in human EGFR-driven NSCLC found that the activation of EGFR through epidermal growth factor stimulation and mutations of 19 deletion or L858R induced PD-L1 expression in human NSCLC cells [102,103]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.