CD274 and lung cancer: Other recent work has shown that Hippo kinases including mammalian STE20-like kinase 1 and 2 (MST1/2), and large tumor suppressor 1 and 2 (LATS1/2), suppress PD-L1 expression, whereas the two main mediators of the Hippo pathway—TAZ and YAP—enhance PD-L1 levels in lung cancer cell lines [114,115].