CD274 and non-small cell lung carcinoma: To date, 4 anti-PD-1/PD-L1 ICIs, pembrolizumab, nivolumab (anti-PD-1), atezolizumab and durvalumab (anti-PD-L1), have been approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced NSCLC.