PPARGC1A and metabolic dysfunction-associated steatotic liver disease: Analysis of missense variants in TET1 and TET2 revealed a putative role for the TET1 locus in the modulation of apoptosis and liver injury in NAFLD, while the TET2 locus is mostly involved in regulating the methylation/demethylation balance of the liver PPARGC1α and thus its transcription [49,86].