Delatte et al. used two experimental models, namely SY5Y neuroblastoma cells treated in vitro with buthionine sulfoximine (BSO), a known inducer of oxidative stress, and double knockout mice lacking both the antioxidant enzymes Gpx1 and Gpx2 (Gpx1/2 DKO mice), to study the global patterns of 5hmC in response to oxidative stress [66]. This evidence concerns the gene GPX1 and neuroblastoma.