Moreover, as reported previously, CD4+ TH1 cells are the principle orchestrators of HSK in the mouse model, whereas CD4+CD25+ Treg cells play a protective role against eye disease.42 We measured the levels of IFN-γ secretion by TH1 cells and also measured CD4+ Treg in corneas and found that the levels of IFN-γ secretion by TH1 cells and CD4+CD25+ T cells matched in both the infected groups on day 28 PI. The gene discussed is CD4; the disease is eye disorder.