To do so, we analyzed the association between four SNPs, including rs1042522, rs17878362, rs2287499, and rs2287498, which refer to R72P substitution in exon 4 of TP53 [25], a 16 bp duplication in intron 3 of TP53 [26], a R68G substitution in the first exon of WRAP53 [27], and a WRAP53 Ex2+19 C>T polymorphism, respectively, in Iranian-Azeri women to validate the question of “whether this haplotype has a potential to be utilized as a prognostic biomarker for breast cancer or not”. This evidence concerns the gene TP53 and breast cancer.