To clarify the relationship between biomarkers and the SYNTAX score in CHD patients, we performed Spearman rank correlation analysis, which showed that the SYNTAX score was positively correlated with NGAL (r = 0.363, P<0.001) (Fig 2A), MMP-9 (r = 0.377, P<0.001) (Fig 2B) and hs-CRP (r = 0.163, P = 0.011) (Fig 2C), while SYNTAX score was not correlated with IL-1β (r = -0.043, P = 0.510) (Fig 2D). This evidence concerns the gene MMP9 and coronary artery disorder.