TARDBP and amyotrophic lateral sclerosis: The toxicity conferred by TDP‐43 in ALS is thought to be partly loss‐of‐function caused by sequestration in insoluble aggregates limiting transcriptional regulation, and partly due to a gain‐of‐function where cytotoxic cytoplasmic aggregates can lead to the dysregulation of proteostasis and sequester other aggregation prone proteins causing further cytotoxicity and contributing to cell death 6.