Twelve cross-connected pathway protein pairs were common to all five pathways and 141 pairs shared by the Ras, EGFR, AKT and MAPK pathways indicating high connectivity between them, and their cross-connection with metabolic pathways suggesting important roles of the respective proteins in EGFR-mutated GBM (S5B Fig for pairs, C for genes left). This evidence concerns the gene EGFR and glioblastoma.