All signaling pathway inhibitors have pronounced negative effects on the viability of both GBM tumor cell lines (Fig 9) but U87MGvIII is significantly more sensitive to the inhibition of casein kinase than the wild-type whereas the wild-type is more sensitive to the inhibition of PLCG1, ABL1 and BCL2. The gene discussed is PDIK1L; the disease is glioblastoma.