Applying this model from 437,449 probable GBM-specific S-M paths, we identified 2,253 (Z≥1) (0.52%) and 876 (Z≥3) (0.20%) significant paths of information flow in mutated EGFR-dependent compared to wtEGFR EGF-driven GBM. The gene discussed is EGFR; the disease is glioblastoma.