Together, in EGFR-mutated GBM, these four signaling pathways were involved in the highest number of SM cross-connections with metabolic pathways: 368, 344 and 298 cross-connecting paths were found between the fourteen signaling pathways and 327, 326 and 289 cross-connected SM pairs involving the amino acid, nucleotide and carbohydrate metabolism, respectively (S2 Table). The gene discussed is EGFR; the disease is glioblastoma.