These are collectively discussed as “tubulinopathies.” Many variants leading to malformations of cortical development have now been identified in TUBULIN, ALPHA-1A (TUBA1A) [2–18]; TUBULIN, BETA-2A (TUBB2A) [19–22]; TUBB2B [4, 5, 15, 23–29]; TUBB3 [2, 15, 30, 31]; TUBB4A [32]; and TUBB/TUBB5 [33]. This evidence concerns the gene TUBB4A and tubulinopathy.