MSH6 and cancer: Based on the ClinVar database from 2015, the current WES of g.MMR genes in 1058 cancer patients demonstrated three (0.3%) pathogenic variants (MLH1 c.545 + 2T>C, MLH1 c.2041G>A [p.Ala681Thr], and MSH6 c.1126G>T [p.Glu376*]) in three patients, two (0.2%) likely pathogenic variants (MLH1 c.453G>A [p.Thr151=] and MLH1 c.1153C>T [p.Arg385Cys]) in two patients (Table 2), 24 VUSs in 68 patients, and 17 likely benign variants in 119 patients (Table S1).