Two cases judged as likely pathogenic variants based on ClinVar database edited in 2015 (case 4: lung cancer case with MLH1 [c.453G>A]; and case 5: sigmoid colon cancer case with MLH1 [c.1153C>T]) were re‐categorized as VUSs by the ClinVar 2018 database. The gene discussed is MLH1; the disease is sigmoid colon cancer.