SLC5A2 and acute kidney injury: Moreover, the proximal tubule is thought to make little use of reabsorbed glucose under normal conditions, but acute kidney injury may induce a relevant glycolytic shift in the outer medullary proximal tubules,19,20 an effect that could involve the tubular upregulation of HIF-1α.21 Whether the increased delivery of glucose to this region of the kidney via SGLT2 inhibition is detrimental or beneficial in conditions of acute kidney injury remains to be determined.