Since, L‐ORD progresses with age, we tested whether preincubation of HTRA1 with WT‐CTRP5, S163R‐CTRP5, or a mixture of WT‐CTRP5 and S163R‐CTRP5 would affect the protease activity of HTRA1. This evidence concerns the gene HTRA1 and late-onset retinal degeneration.