Deposit‐forming retinal phenotypes are observed in two monogenic, dominant macular degenerations, Doyne honeycomb retinal dystrophy (DHRD) due to mutations in EGF containing fibulin extracellular matrix protein 1 (EFEMP1) and Sorsby fundus dystrophy (SFD) due to mutations in tissue inhibitor of metalloproteinase‐3 (TIMP3), in addition to the common condition AMD (Fu et al., 2007; Klenotic, Munier, Marmorstein, & Anand‐Apte, 2004). Here, ECM1 is linked to Doyne honeycomb retinal dystrophy.