A plethora of molecular mechanisms/pathways have been illustrated to be involved in CKD pathology, such as vascular calcification and stiffness due to an imbalance in calcium and phosphate levels [16], the renin-angiotensin-aldosterone system (RAAS) [17], endothelial dysfunction [18], inflammation [19], coagulation processes [20], and oxidative and metabolic stress [21, 22]. This evidence concerns the gene REN and endothelial dysfunction.