The WT1-specific peptide containing H2-IAb-restricted CRYGPFGPPPSQAS and H2-Db-restricted RMFPNAPYL epitopes6, 8 was injected i.p. to ID8-T-bearing mice (50 μg/injection) 3 days after FL delivery (Figure 6A) in combination with poly(I:C) (50 μg/injection), which binds to TLR3 expressed on CD103+ DCs40 and induces type I IFN production and DC maturation.41, 42 Additional groups of tumor-bearing mice received only virotherapy treatments before immunization to determine the importance of FL-expanded CD103+ DCs in the induction of tumor-antigen-specific T cells and inhibition of tumor growth. This evidence concerns the gene TLR3 and neoplasm.