Conversely, exposure of rabbit jejunal tissue to verapamil did not reduce D‐glucose uptake.61, 62 However, verapamil was shown to improve glucose tolerance 63 and reduce serum glucose levels in T2DM patients.64, 65 The local anesthetics bupivacaine, levobupivacaine and ropivacaine, as well as the antidepressant trimipramine also emerged as novel SGLT1/2 inhibitors in this study. Here, SLC5A1 is linked to type 2 diabetes mellitus.