SGLT1–mediated transport of the glycoside polydatin, found in grape juice,39 has been reported.40 Polydatin ameliorated T2DM conditions in in vitro and animal models via various downstream mechanisms.41, 42, 43 Novel SGLT inhibiting glycosides found here are isoliquiritin from Glycyrrhizae radix (Liquorice) and prunetin‐4p‐galactoside from Dalbergia spinose roxb, which showed some SGLT1 selectivity. This evidence concerns the gene SLC5A1 and type 2 diabetes mellitus.