SLC5A1 and hyperinsulinism: Notably, hypoglycemia is recognized as a comorbidity of malaria with complex multifactorial etiology, including quinine or quinidine induced hyperinsulinemia.54, 55, 56 Unchanged renal clearance has been shown for quinine,57 so it could be speculated that these drugs may inhibit intestinal SGLT1 and renal SGLT2, contributing to blood glucose lowering.