However, alternative hypotheses as to why toluene reduces adiposity are that it affects the absorption of ingested fats within the digestive tract, or the ability to depose lipids within adipose tissue, such as that observed in pancreatic disorders.76 For example, both leptin and insulin play a crucial role in regulating lipogenesis77 and, therefore, the observed disruptions to hormones involved in energy balance signaling, including insulin,27 may impair the deposition of lipids in adipose tissue. This evidence concerns the gene INS and pancreas disorder.