NR3C2 and congestive heart failure: Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs), beta-blockers (BBs) and mineralocorticoid receptor antagonists (MRA) have been shown to improve clinical condition and survival of patients with CHF with reduced ejection fraction (HFrEF).2 Diuretic therapy helps to reduce cardiac load with improvement in left ventricular (LV) function.3 Mortality and morbidity after symptomatic CHF have remained high although variable which could be due to differences in severity of disease and appropriate use of evidence-based treatment.