A phase III study (RTOG 1010) evaluating role of Trastuzumab to enhance response to chemoradiotherapy and surgery is ongoing, although positive findings will likely benefit only up to 15–20% of patients as frequency of HER2-neu overexpression is observed in <20% of esophageal adenocarcinoma [7]. This evidence concerns the gene ERBB2 and esophageal adenocarcinoma.