Consistent with these data, we demonstrated that GREM1 mRNA levels are significantly higher in CRC primary tumour tissue, which contains all components of the TME, compared to epithelial stem cells, which are devoid of other TME lineages such as fibroblasts (GSE33114 [20] p< 0.0001; Figure 2B). The gene discussed is GREM1; the disease is neoplasm.