We confirmed the association between high levels of GREM1 mRNA and disease recurrence, using a previously described cohort of stage II CRC [19] (GSE33113 [20]; n = 90; Figure 1A left), in addition to validation of these findings in a further independent CRC cohort (GSE39582 [21]; n = 557; Figure 1A right). Here, GREM1 is linked to colorectal carcinoma.