Furthermore, other PLA2 toxinsfrom snakes of the genus Bothrops may trigger apoptosis of tumorcells, such as BnSP-6 from Bothrops pauloensis, which elicitsphosphatidylserine externalization, upregulates expression of the pro-apoptoticcaspase 8 gene and downregulates expression of the anti-apoptotic Bcl-2, Bcl2l1, andBIRC-5 genes in MDAMB231 triple-negative breast cancer cells [24]. Here, BCL2 is linked to triple-negative breast carcinoma.