In order to understand the role of ANGPTL2 in thyroid cancer cell proliferation, TPC-1 thyroid cancer cells were transfected with an expression construct carrying either cDNA ANGPTL2 or siRNA-ANGPTL2 respectively, which results in either overexpression or down regulation of ANGPTL2 in TPC-1. This evidence concerns the gene ANGPTL2 and thyroid cancer.