The key findings of this study were: (1) ANGPTL2 expression was higher in thyroid cancer cell in comparison to adjacent normal thyroid tissue cell; (2) ANGPTL2 expression was increased with thyroid tumor progression; (3) high expression of ANGPTL2 enhanced proliferation of thyroid cancer cells; (4) ANGPTL2 promoted cell migration and invasion of thyroid cancer cells; (5) higher level of ANGPTL2 in thyroid cancer patients were significantly associated with a poor prognosis. The gene discussed is ANGPTL2; the disease is thyroid gland carcinoma.