Following literature review, we investigated targets reportedly upregulated in HCC according to the TGCA cohort, including TXNRD1, protein phosphatase Mg2+/Mn2+-dependent-1F, and Cbl proto-oncogene B. qRT-PCR analysis of their mRNA levels in miR-125b-5p-overexpressing or silenced HCC cells revealed that only TXNRD1 was regulated by miR-125b-5p (Fig. 4a, b). The gene discussed is TXNRD1; the disease is hepatocellular carcinoma.