DIO3OS and pachyonychia congenita: We found that the level of miR-122 was downregulated, while the expression of ALDOA was upregulated in PC tissues compared with normal samples (Fig. 1g, h), indicating a negative correlation between DIO3OS and miR-122 expression (Fig. 1b, g), and a negative association between miR-122 and ALDOA expression in PC samples (Fig. 1g, h).