miRNA 106b~25 has been reported to be up-regulated in several cancers, including esophageal squamous cell carcinoma [21], breast cancer [19], hepatocellular carcinoma [20] et al. The regulation targets of miRNA 106b~25 involving E2F1 and TGF-β, RB, TP53 [23], PTEN [24] et al. All these targets play crucial role as an intrinsic factor of gastric carcinogenesis. Here, PTEN is linked to esophageal squamous cell carcinoma.