FUS and frontotemporal dementia: Of particular interest here, mutations in the highly conserved NLS region of the FUS gene, which encodes a protein that is involved in RNA transcription and processing, have been described in ALS and in ALS with frontotemporal dementia (ALS/FTD) (Dormann and Haass, 2013; Hewitt et al., 2010; Nolan et al., 2016; Rademakers et al. 2010).