As described in Figure 5, target genes were significantly enriched in repressor activator protein 1 (Rap1), HIF-1, p53, renin secretion, proximal tubule bicarbonate reclamation, gastric acid secretion, pancreatic secretion, malaria, inflammatory bowel disease, and rheumatoid arthritis signaling pathways as well as advanced glycation end-product (AGE)-receptor for advanced glycation end-product (RAGE) signaling pathway in diabetic complications. Here, REN is linked to rheumatoid arthritis.