In the present study, we assessed the performance of the established clinical predictors of PCa outcome, and DNA methylation of three TSGs, known to be associated with PCa [6, 11]—retinoic acid receptor β (RARB), RAS association domain family member 1 (RASSF1), and glutathione S-transferase pi 1 (GSTP1)—as potential noninvasive biomarkers for more accurate PCa risk assessment. This evidence concerns the gene RARB and posterior cortical atrophy.