Although, mitochondrial functions modulated by PGC-1α positively impact the in-vivo growth of breast cancer cell lines [10], human tumor transcriptional data, cell culture, and in-vivo mouse experiments revealed that a PGC1α-modulated transcriptional program promotes oxidative metabolism and a universal catabolic state to restrain PCa growth and metastasis [11]. This evidence concerns the gene PPARGC1A and breast carcinoma.