Treatment of sh-PLCε-transfected PCa cells with1 nM GW501516, a highly selective agonist of PPARβ, prevented the PLCε depletion-mediated decreases in Twist1 mRNA and protein, while GSK3787 (1 μM), an inhibitor of PPARβ, enhanced PLCε depletion-mediated Twist1 repression (Fig. 7a, b and Additional file 1: Figure S5a-c). This evidence concerns the gene PPARD and posterior cortical atrophy.