In their analysis, seven CpGs in the gene body of EBF3 (chr10:131636622–131671489, GRCh37; cg03774288, cg07890827, cg09121772, cg09371530, cg09649486, cg16803064 and cg25866634) showed significant loss of methylation in metastases compared to benign nevi, and one of these CpG sites showed the same degree of hypomethylation in metastases compared to primary melanoma. The gene discussed is EBF3; the disease is melanoma.