AKT1 and Other metabolic disease: The GO term, which is related to the transport of proteins and organic substances, showed enrichment (Fig. 4), along with the pathways related to development (hippo signaling pathway and hippo signaling pathway—fly), signal transduction (PI3K-Akt, AMPK, sphingolipid signaling pathway and Jak-STAT signaling pathways), cellular community (tight junction and focal adhesion), metabolic diseases (insulin resistance) and transport (endocytosis) (Fig. 5).