It may also serve as a prognostic factor in characterizing subsets of glioblastoma multiforme [42], as patients with CXCR4-positive gliomas seem to have a worse prognosis after surgery and is associated with an angiogenic switch in recurrence of glioblastoma after radio-chemotherapy [43, 44]. The gene discussed is CXCR4; the disease is glioblastoma.