In an older study, we analysed the BRAF mutational status in 112 MPM patients (96 with two, 15 with three and one with four MPMs) [9]; BRAF mutations were detected in 48% of the 229 primary lesions examined, which is in accordance with figures of sporadic CMM in the general population, and consistently lower with those found in our study. The gene discussed is BRAF; the disease is familial congenital mirror movements.