Down-regulation of MALAT1 leads to a reduction of the migratory capacity of MDA-231 and MCF10A + TGF-β cells (Fig. 3b-e, in the absence of TGF-β MCF10A capacity to migrate is abolished (data not shown)), in agreement with previous reports in other cancer models [10, 42]. This evidence concerns the gene TGFB1 and cancer.