TGFB2 and ocular hypertension: Since perfusion of ex vivo organ culture of human anterior segment with activated TGFβ2 increases IOP [17], and intraocular injection of adenoviral encoding the bioactive TGFβ2 causes ocular hypertension in both the rat and mouse [23], the increased TGFβ2 in AACG patients with high IOP may further exacerbate the glaucomatous conditions in the eye.