We found that (1) POAG patients had a higher concentration of TGFβ2 in their AH, (2) AACG patients with high IOP had elevated levels of both cytokines compared to those with normal IOP, and (3) there was a difference in SFRP1 between normal and high IOP sub-groups in POAG patients. Here, TGFB2 is linked to open-angle glaucoma.