The authors demonstrated that all inflammatory markers including tumor necrosis factor (TNF)-α, pentraxin-3 (PTX-3), interleukin (IL)-6, and hs-CRP in blood samples were significantly higher in PD patients with diabetic nephropathy than in the other two groups, and TNF-α was reduced after 3 months of periodontal treatment in all patients [23]. The gene discussed is TNF; the disease is diabetic kidney disease.