SERPINE1 and deep vein thrombosis: Plasminogen activator inhibitor type-1 (PAI-1, SERPINE1) is a major promoter of vascular-related pathologies, including arterial thrombosis and perivascular fibrosis [36,37] as well as a biomarker and prognostic indicator of TGF-β1-stimulated neointima formation and disease progression [21,36,38,39,40].