Even publications that report divergent findings related to the involvement of caveolin-1 in EGF-dependent EGFR activation and cell migration, a key aspect of VSMC dysfunction in cardiovascular disease, conclude that caveolin-1 overexpression inhibits growth of various cells including VSMCs [76,77,78], a prelude to entry into a senescent end-state. This evidence concerns the gene EGF and cardiovascular disorder.