Collectively, these findings suggest that continued identification of molecular mechanisms underlying caveolin-1-dependent senescence-associated signaling pathways (e.g., TGF-β1/src kinase/p53) that regulate expression of specific caveolin-1-regulated senescence-conferring genes (e.g., PAI-1) may provide novel targets for the therapy of cardiovascular disease. This evidence concerns the gene SERPINE1 and cardiovascular disorder.