Taken together, hyperacute serum can be a promising blood separation product in degenerative joint diseases, which enhances cell proliferation, the production of COL1A1 and osteonectin, while decreasing the level of RANKL, IL-1β, IL-6Rα, IL-12, and TNF-α (Figure 9). The gene discussed is TNFSF11; the disease is osteoarthritis.