Besides, in the omics era, SOD2 genotyping could, together with a panel of other enzymes shown to be associated with susceptibility to BEN, (GSTA1, GSTM1, GSTT1, CYP3A5, NQO1) be potentially applied as a biomarker of susceptibility in BEN areas [23,44,45,46]. Here, SOD2 is linked to Balkan nephropathy.