Similarly, Akbarpour et al. showed that sleep fragmentation (SF) and IH (6% Fi O2, 90 s hypoxia, 90 s reoxygenation, 20 cycles per hour, 12 h per day till the tumor is palpable) increased tumor size and invasiveness, and IH reduced granzyme-B producing CD8+ cells in tumors of OSA TC1 mice model [148]. The gene discussed is CD8A; the disease is obstructive sleep apnea syndrome.