PAX8 immunoreactivity and CD68 (PG-M1) negativity supports the diagnosis of t(6;11) renal cell carcinoma, whereas pure epithelioid PEComa/epithelioid angiomyolipoma is PAX8 negative and CD68 (PG-M1) positive [42]. This evidence concerns the gene CD68 and hereditary clear cell renal cell carcinoma.