Some tumor type selectivity was suggested by this analysis, with the strongest dependency detected for CDK8 by CRSPR assays in tumors of the central nervous system (designated Med Group 3) (Figure 2), and among the other enriched lineages, hematopoietic malignancies were identified as dependent on CDK19 by RNAi analysis (Figure 2). This evidence concerns the gene CDK19 and nervousness.