Figure 1 compares the overall distributions of DepMap dependency scores derived from CRISPR analysis of a panel of 563 tumor cell lines and RNAi analysis of a panel of 713 cell lines, for cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6, left column), transcriptional CDKs (CDK7, CDK9, and CDK12, middle column), and CDK8, CDK19, and CCNC (right column). The gene discussed is CDK8; the disease is neoplasm.